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We’re not exactly known for our sense of humor around these parts. Our Very Serious Interests range from locally raised, ethically harvested kale to debates on whether Nancy Pelosi is liberal enough. But San Francisco does have a comedy scene—it’s just a little weirder, a lot less commercial, and often much funnier than what you’ll find elsewhere, and the Business, held every Wednesday night inside the Mission’s Darkroom theater, is at its rumbling epicenter. Founded in 2009 by local comedians Sean Keane, Alex Koll, Chris Garcia, and Bucky Sinister, the Business has become the place to see edgy, often pee-in-your-pants-funny stand-up. “San Francisco has a lot of self-proclaimed comedy ‘nerds,’ and that only helps alternative rooms like ours,” says cofounder Keane. It’s already known to host a menagerie of talented locals, such as Beth Lisick and Nato Green, and now the word is out that national headliners and Comedy Central regulars like Todd Barry, W. Kamau Bell, and Laurie Kilmartin often stop by, so the demand for tickets to the Business is growing. And because this is San Francisco, you know there will be at least one political comedian on the roster, so you won’t have to feel too bad for skipping that protest to attend. 2263 Mission St., 415-401-7987